1640s, "full of regret," from regret + -ful. Regretfully, properly "with regret," incorrectly used in place of regrettably "it is to be regretted that; calling for regret" since at least 1965. "A regrettable use, prob. after HOPEFULLY adv.2" [OED].[regretful etymology, regretful origin, 英语词源]