1640s, noun of action from verb enucleate (1540s), from Latin enucleatus "pure, clean," past participle of enucleare "to lay open, explain in detail," literally "to remove the kernel from" (see ex- + nucleus). Mostly figurative in Latin (the notion is of getting at the "core" of some matter), and usually figurative in English until mid-19c. advances in science and medicine gave it a new literal sense.[enucleation etymology, enucleation origin, 英语词源]